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Capillary leak syndrome is when blood plasma escapes through capillary walls, which can cause a rapid drop in blood pressure. 50% of patients experience fatigue, edema, weight gain, polydipsia, nausea. Studies employing chest radiographs or serial ultrasonography to detect plasma leakage directly have demonstrated that progressive and significant accumulation of fluid only occurred in a subset of dengue cases (15, 16)

The extent of plasma leakage has been shown to correlate with the decline in platelet counts (17). Scls attacks consist of a prodromal, extravasation, and recovery phase Pathophysiology — plasma leakage centers for disease control and prevention national center for emerging and zoonotic infectious diseases

Capillary leak syndrome, or vascular leak syndrome, is characterized by the escape of blood plasma through capillary walls, from the blood circulatory system to surrounding tissues, muscle compartments, organs or body cavities

It is a phenomenon most commonly witnessed in sepsis, and less frequently in autoimmune diseases, differentiation syndrome, engraftment syndrome, hemophagocytic. Plasma leakage is the most serious complication that distinguishes dengue from severe dengue In a patient with severe dengue, although plasma leaks from the blood vessels, the red blood cells are. Capillary leak syndrome is a rare disorder that causes a dramatic drop in blood pressure

Early diagnosis is important to ensure proper treatment and better outcomes. Patients with dengue haemorrhagic fever (dhf) as defined in the 1997 world health organization classification are often reported, and they all have plasma leakage, but some patients with plasma leakage do not meet the definition of dhf Systemic capillary leak syndrome (scls), also known as clarkson disease, is a rare disorder in which considerable amounts of plasma and proteins leak from capillaries into surrounding tissue, muscle, and body cavities Capillary leak syndrome occurs when plasma leaks out of capillaries into muscles, tissues, organs and body cavities

There are two major types of capillary leak syndrome

It is a single episode triggered by another disease, condition or drug Idiopathic systemic capillary leak syndrome It is a rare disease characterized by recurrent episodes of acute. Though it was first described in 1960, only 260 cases have been reported

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